Nanofiber Scaffolds with Gradients in Mineral Content for Spatial Control of Osteogenesis
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منابع مشابه
Nanofiber Scaffolds with Gradients in Mineral Content for Spatial Control of Osteogenesis
Reattachment of tendon to bone has been a challenge in orthopedic surgery. The disparate mechanical properties of the two tissues make it difficult to achieve direct surgical repair of the tendon-to-bone insertion. Healing after surgical repair typically does not regenerate the natural attachment, a complex tissue that connects tendon and bone across a gradient in both mineral content and cell ...
متن کاملNanofiber scaffolds with gradations in mineral content for mimicking the tendon-to-bone insertion site.
We have demonstrated a simple and versatile method for generating a continuously graded, bonelike calcium phosphate coating on a nonwoven mat of electrospun nanofibers. A linear gradient in calcium phosphate content could be achieved across the surface of the nanofiber mat. The gradient had functional consequences with regard to stiffness and biological activity. Specifically, the gradient in m...
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of the Dissertation Development of Nanofiber Scaffolds with Controllable Structure and Mineral Content for Tendon-to-Bone Repair
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Background and purpose: Tissue engineering and cell therapy, as promising therapies, provide the opportunity to repair bone lesions and defects. Combined scaffolds, synthetic and natural polymers can provide a suitable structure for differentiation of Wharton Jelly mesenchymal stem cells (WJ-MSCs) into bone. In current study, the effect of lyophilized blood growth factors in promoting the ...
متن کاملThe Role of Biodegradable Engineered Nanofiber Scaffolds Seeded with Hair Follicle Stem Cells for Tissue Engineering
Background: The aim of this study was to fabricate the poly caprolactone (PCL) aligned nanofiber scaffold and to evaluate the survival, adhesion, proliferation, and differentiation of rat hair follicle stem cells (HFSC) in the graft material using electrospun PCL nanofiber scaffold for tissue engineering applications. Methods: The bulge region of rat whisker was isolated and cultured in DMEM: n...
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ژورنال
عنوان ژورنال: ACS Applied Materials & Interfaces
سال: 2014
ISSN: 1944-8244,1944-8252
DOI: 10.1021/am405418g